The set is a combination (Misoprostol+Mifepristone) of two medicines especially used for medical abortion (termination from pregnancy).
The most important for use Misoprostol (Cytotec) is to know the period of pregnancy. There are 2 periods :
0 – 12 weeks ( reduced than 63 days of pregnancy)
13 – 36 weeks (more than 63 days of pregnancy)
Mechanism of action :
Mifepristone, an antiprogesterone , binds towards the progesterone receptor to block the receptor, thus suppressing progesterone from binding. It doesn’t activate a real biologic reaction to progesterone it will, however, have both weak antiglucocorticoid and antiandrogenic activity. Additionally, it softens and dilates the cervix, causes decidual necrosis (which results in placental detachment), increases uterine lining prostaglandin release, increases uterine contractions, and improves uterine sensitivity to given prostaglandin.
Misoprostol, a prostaglandin, binds to myometrial cells to goal strong myometrial contractions leading to expulsion of tissue. This agent also causes cervical ripening with softening and dilation concerning the cervix.
This medication is a orlon steroid, used alone or together with another medication, to end an early pregnancy (within 7 weeks of the start regarding a woman’s newest menstrual period). It blocks the hormone needed for pregnancy to continue.
Contraindicated in those with confirmed or suspected fertilized egg has inserted outdoors the uterus, chronic adrenal failure, parallel lengthy-term corticosteroid therapy, good reputation for allergy to mifepristone, misoprostol or any distinct prostaglandin, bleeding disorders, liver or kidney impairment pregnancy and lactation IUD in position undiscovered uterus mass.
Side effects :Abdominal or stomach pain (mild), DiarrheaBleeding from vagina, constipationcramps in lower abdomen or stomach area, gasheadache, heartburn, indigestion, or acid stomachnausea and/or vomiting
Don’t take this medicines whenever you feel you might be pregnant. It may cause abortion, premature birth, or birth defects. In rare cases, serious complications (e.g., uterine rupture) have occurred when misoprostol was used to start labor or when used in unification with another drug to cause abortion ex post facto the eighth week of pregnancy. These complications have resulted in harm to the unborn baby and mother.
Avoid pregnancy while taking misoprostol moreover for at least one month or person completed menstrual cycle after you have stopped treatment. If you befall pregnant while taking misoprostol, contact your doctor immediately.
Female patients must meet the following four requirements in order to use this drug : 1) proof negative for gravidity within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) endure oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.
Oral – Termination of pregnancy (49 days or less duration) – Adult: 600 mg as a single dose followed 2 days soon by 400 mcg of misoprostol as single dose.
Store at or below 25 degree C. Store away from heat, moisture, and light. Confine out of reach of children.